White Cube Bermondsey opened in October 2011 and is the largest of all the White Cube gallery's sites, incorporating more than 5440m² (58,000 sq ft) of interior space. The building, which dates from the 1970s, was renovated and designed by London and Berlin-based architects Casper Mueller Kneer and includes three major exhibition spaces as well as private viewing rooms, office space, a warehouse, an auditorium and a bookshop.

The 'South Galleries' provide the principal display area for White Cube's expanding programme of exhibitions and three smaller galleries, known collectively as the 'North Galleries', are used for an innovative series of shows. In addition, at the centre of the building, a top-lit, 81m² gallery entitled '9 x 9 x 9', is used for special projects or for the display of a single artwork or installation.

Since its inception, the building has hosted a variety of important exhibitions such as the first UK showing of work by American artist Theaster Gates, a comprehensive retrospective of prints by Chuck Close and the largest presentation of Anselm Kiefer work's ever staged in London. To accompany these exhibitions, an education programme and an ongoing series of artists films, feature films and lectures takes place in the purpose-built 60 seat auditorium.